The contest was played before a capacity crowd of 87,101 - the second largest crowd ever to see Sam Houston play football. An audience of 88,913 saw the Bearkats play Texas in Austin in 2006.
Quarterback Brian Bell passed for 140 yards and a touchdown and running backs Timothy Flanders and Ridgeway Frank and backup quarterback Chris Grett each scored a TD as Sam Houston gained 382 total yards against the Aggie defense.
Flanders got the Bearkats on the scoreboard with a two-yard run with 1:08 to play in the third, completing an 18 play, 75-yard drive that used 9:33 seconds.
After a successful on sides kick, Bell hit K. J. Williams for a nine-yard TD pass at the 14:20 mark, finishing a four play 49-yard drive.
Frank scored on a one-yard run with 5:37 to play and Grett tallied on a five-yard run with 2:42 to go to complete the scoring.
Flanders rushed 21 times for 64 yards, Grett five times for 48 and Frank 10 for 47.
A&M quarterback Johnny Manziel rushed 16 times for 100 yards and two touchdowns and completed 14 of 20 passes for 267 yards and three scores.
Dax Swanson tied a 53-year-old school record with his 13th career interception with six minutes remaining in the second quarter. Swanson also force and recovered an Aggie fumble in the second half.
The Aggies opened the game driving 72 yards in 12 plays in 4:23 to go up 7-0. Manziel passed seven yards to Mike Evans for the score.
Two punts by Matt Foster fair caught at the Aggie five yard line kept A&M bottled up until the start of the second quarter. A&M drove 95-yards in eight plays with two 15-yard personal foul calls helping the cause for the Aggies' second tally. Manziel again found Evans for a 10-yard score at the 10:43 mark.
Two turnovers in the final five minutes of the half set up 20 points for the Aggies.
Manziel scored on a four-yard run 4:11 before half to up the margin to 20-0. The three-play 13-yard drive was set up by an interception by Donnie Baggs.
Trey Williams scored on a four-yard run at 1:49 and Manziel rushed over from the one with 1:24 remaining following a Sean Porter fumble recovery to send the Aggies to the dressing room at halftime with a 34-0 lead.
Manziel threw an 89-yard touchdown pass to Uzoma Nwachukwu and backup quarterback hit LeKendrick Williams for an 80-yard pass to put A&M up 47-0 with 10:41 left in the third period.
Sam Houston awaits word from the NCAA selection committee as to the Bearkats' Division I Football Championship playoff future. The 2012 bracket and seedings will be announced Sunday at 12:30 p.m. on ESPNU.