Preseason All-Southland Conference junior forwards Britni Martin and Sequeena Thomas both scored 21 points to lead Sam Houston (12-9, 7-3). Chanice Smith added 12 points.
Myeisha Myles led A&M-Corpus Christi (8-14, 4-5) with 11 points.
The Islanders led by as many as 14 points in the first half as Jessica Jammer's layup gave TAMUCC a 31-17 lead with 5:21 playing in the first half.
Smith hit a three-pointer with 4:45 left in the period to start a first half ending 12-4 run as the Islanders went into the locker roomer up 35-29.
The Kats came out hot in the second half, outscoring the Islanders 16-6 in the opening six minutes of the second period. Martin put Sam Houston up 40-37 with a three-pointer at the 16:33 mark and the Kats never trailed again.
Point guard Khamra Echols totaled eight assists and three steals.
"When we were down, it didn't feel like we were down," Smith said. "We kept focused and didn't get down on ourselves. We knew we had to come back."
The Bearkat defense scored 17 points off A&M-Corpus Christi's 16 turnovers. Sam Houston won the rebounding war with 40 boards to 34 for the Islanders.
Thomas her 13th game of the season with double figure points and rebounds as she pulled down 15 boards. Smith added eight boards and Jasmine Johnson pulled down five. Johnson and Angela Beadle each scored six points and Echols added five.
"Once we started hitting shots, everything opened up," Martin said. "We're out to keep this momentum going and go strong into the post season tournament."
The Bearkat women now take a week off before traveling to Conway, Ark., to face Central Arkansas next Saturday.